基因名称:MYOD1 (myogenic differentiation 1)
别名: PUM,MYF3,MYOD,bHLHc1
基因ID:4654
Chromosome(GRCh37) :11 Start: 17741110 End: 17743678 Strand:
信号通路:
靶向药:
化疗药:
简介:该基因编码一种核蛋白,属于转录因子和肌生成因子亚家族的基本螺旋环螺旋家族。它通过诱导细胞周期停滞来调节肌肉细胞分化,这是肌源性启动的先决条件。这种蛋白质也参与肌肉再生。它激活自身的转录,可能稳定对肌生成的承诺。[由RefSeq提供,2008年7月]This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008]
MYOD1突变与药物: