数据库名称：ProCan-DepMapSanger
数据库简述：
所属国家/地区：Australia
数据库主要信息：The proteome provides unique insights into disease biology beyond the genome and transcriptome. A lack of large proteomic datasets has restricted the identification of new cancer biomarkers. Here, proteomes of 949 cancer cell lines across 28 tissue types are analyzed by mass spectrometry. Deploying a workflow to quantify 8,498 proteins, these data capture evidence of cell-type and post-transcriptional modifications. Integrating multi-omics, drug response, and CRISPR-Cas9 gene essentiality screens with a deep learning-based pipeline reveals thousands of protein biomarkers of cancer vulnerabilities that are not significant at the transcript level. The power of the proteome to predict drug response is very similar to that of the transcriptome. Further, random downsampling to only 1,500 proteins has limited impact on predictive power, consistent with protein networks being highly connected and co-regulated.
建立年份：2022
联系信息：Contact information
University/Institution:
University of Sydney
Address:
ProCan®, Children’s Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia.
City:
Province/State:
Country/Region:
Australia
Contact name (PI/Team):
Roger R Reddel
Contact email (PI/Helpdesk):
rreddel@cmri.org.au
