数据库简述：Breast Cancer PDTX Encyclopaedia
数据库主要信息：The inter- and intra-tumor heterogeneity of breast cancer needs to be adequately captured in pre-clinical models. We have created a large collection of breast cancer patient-derived tumor xenografts (PDTXs), in which the morphological and molecular characteristics of the originating tumor are preserved through passaging in the mouse. An integrated platform combining in vivo maintenance of these PDTXs along with short-term cultures of PDTX-derived tumor cells (PDTCs) was optimized.The biobank represents a powerful resource for pre-clinical breast cancer pharmacogenomic studies including identification of biomarkers of response or resistance.
University of Cambridge
Department of Oncology and Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge CB2 0RE, UK
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