该基因编码的蛋白质参与了电离辐射和烷化剂对DNA单链断裂的有效修复。该蛋白与DNA连接酶III、聚合酶β和聚ADP核糖聚合酶相互作用，参与碱基切除修复途径。在生殖细胞减数分裂和重组过程中可能在DNA加工中起作用。该基因罕见的微卫星多态性与不同放射敏感性患者的癌症有关。The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
基因名：
XRCC1
别名：
RCC
基因ID：
7515
Chromosome：(GRCh37)
19 Start: 44047192 End: 44084625 Strand: -1
信号通路：
细胞周期
基因组不稳定
靶向药：
化疗药：
卡铂 顺铂 多西他赛 吉西他滨 长春瑞滨